GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs8141797 | 1 | rs5760220 | chr22:24542480 | SUSD2 | chr22:24577444-24585074:+ | 0.32 | 3.77 | 0.000182 | Amyotrophic lateral sclerosis |
| THCA | cis | rs8141797 | 1 | rs5760229 | chr22:24560254 | SUSD2 | chr22:24577444-24585074:+ | 0.32 | 3.82 | 0.000152 | Amyotrophic lateral sclerosis |
| THCA | cis | rs5752326 | 1 | rs5761529 | chr22:26843708 | HPS4 | chr22:26847447-26879820:- | 0.3 | 3.76 | 0.000195 | Ischemic stroke |
| THCA | cis | rs5752326 | 1 | rs5761530 | chr22:26843916 | HPS4 | chr22:26847447-26879820:- | 0.32 | 4.32 | 1.91E-5 | Ischemic stroke |
| THCA | cis | rs1552244 | 1 | rs57631744 | chr3:10118962 | C3orf10 | chr3:10157333-10168873:+ | -0.2 | -4.18 | 3.51E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs57631744 | chr3:10118962 | VHL | chr3:10183319-10193744:+ | -0.19 | -4.37 | 1.54E-5 | Alzheimer's disease |
| THCA | cis | rs8135828 | 1 | rs5763305 | chr22:29930195 | NIPSNAP1 | chr22:29950800-29977144:- | -0.24 | -3.6 | 0.000346 | Lipid traits |
| THCA | cis | rs7224314 | 1 | rs57672368 | chr17:65358688 | PSMD12 | chr17:65336620-65362721:- | -0.17 | -3.41 | 0.000698 | Diisocyanate-induced asthma |
| THCA | cis | rs6832769 | 1 | rs576779 | chr4:56274307 | TMEM165 | chr4:56262090-56292342:+ | -0.16 | -4.13 | 4.25E-5 | Personality dimensions |
| THCA | cis | rs4888671 | 1 | rs57678958 | chr16:77785315 | NUDT7 | chr16:77756411-77776153:+ | 0.36 | 4.91 | 1.25E-6 | Obesity-related traits |
| THCA | cis | rs867186 | 1 | rs57690120 | chr20:33731437 | MMP24 | chr20:33814539-33864804:+ | -0.21 | -3.36 | 0.00084 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs867186 | 1 | rs57690120 | chr20:33731437 | PROCR | chr20:33758727-33765164:+ | -0.3 | -5.19 | 3.07E-7 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs867186 | 1 | rs57690120 | chr20:33731437 | TRPC4AP | chr20:33590215-33680618:- | 0.29 | 3.79 | 0.000168 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs73201462 | 1 | rs57699322 | chr3:128065313 | EEFSEC | chr3:127872313-128127488:+ | -0.2 | -3.49 | 0.00053 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs3136441 | 1 | rs57704144 | chr11:46770359 | ZNF408 | chr11:46722368-46727461:+ | -0.18 | -3.59 | 0.000368 | HDL cholesterol |